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- Title
BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells.
- Authors
Gould, Stephen E; Day, Maria; Jones, Simon S; Dorai, Haimanti
- Abstract
Proximal tubule epithelial cells (PTEC) play a central role in the response of the kidney to insult by virtue of their production of chemokines and cytokines that signal an inflammatory response. Bone morphogenic protein-7 (BMP-7/OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has previously been demonstrated to reduce macrophage infiltration and tissue damage in animal models of acute and chronic renal failure. The present study was designed to define the molecular mechanism of BMP-7 action in human PTEC.
- Publication
Kidney international, 2002, Vol 61, Issue 1, p51
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2002.00103.x