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- Title
Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy.
- Authors
Mizuno, S; Matsumoto, K; Nakamura, T
- Abstract
As tubulointerstitial fibrosis (TIF) reflects the prognosis of patients with various chronic renal diseases, the pathogenesis of TIF has to be clarified. Transforming growth factor-beta (TGF-beta) is a key mediator for renal fibrosis. We reported that hepatocyte growth factor (HGF) prevents renal fibrosis in nephrotic mice. However, the function of HGF in chronic renal failure, except for nephrotic syndrome, remains to be determined.
- Publication
Kidney international, 2001, Vol 59, Issue 4, p1304
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2001.0590041304.x