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- Title
Hydrogen peroxide increases extracellular matrix mRNA through TGF-beta in human mesangial cells.
- Authors
Iglesias-De La Cruz, M C; Ruiz-Torres, P; Alcamí, J; Díez-Marqués, L; Ortega-Velázquez, R; Chen, S; Rodríguez-Puyol, M; Ziyadeh, F N; Rodríguez-Puyol, D
- Abstract
Reactive oxygen species (ROS) are excessively produced in pathologic states, including many renal diseases. Transforming growth factor-beta (TGF-beta) may mediate renal fibrotic injury, and ROS may act through the TGF-beta pathway to exert a profibrotic effect.
- Publication
Kidney international, 2001, Vol 59, Issue 1, p87
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2001.00469.x