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- Title
Effects of diabetes and hypertension on glomerular transforming growth factor-beta receptor expression.
- Authors
Kang, M J; Ingram, A; Ly, H; Thai, K; Scholey, J W
- Abstract
Several studies have suggested that transforming growth factor-beta1 (TGF-beta1) is an important determinant of diabetic glomerular injury. TGF-beta1 forms a heteromeric complex with two cellular receptor subtypes, designated TGF-beta RII and TGF-beta RI, but the effects of diabetes mellitus on glomerular TGF-beta receptor expression have not been completely elucidated. We first compared the effect of experimental type I diabetes mellitus and uninephrectomy on glomerular TGF-beta receptor expression in spontaneously hypertensive rats (SHRs), and then sought to determine whether changes in TGF-beta receptor expression were strain specific by studying normotensive Wistar-Kyoto (WKY) rats.
- Publication
Kidney international, 2000, Vol 58, Issue 4, p1677
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2000.00328.x