We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: possible role of lysophospholipid.
- Authors
Kohjimoto, Y; Honeyman, T W; Jonassen, J; Gravel, K; Kennington, L; Scheid, C R
- Abstract
Exposure to high levels of oxalate induces oxidant stress in renal epithelial cells and produces diverse changes in cell function, ranging from cell death to cellular adaptation, as evidenced by increased DNA synthesis, cellular proliferation, and induction of genes associated with remodeling and repair. These studies focused on cellular adaptation to this oxidant stress, examining the manner by which oxalate exposure leads to increased expression of immediate early genes (IEGs). Specifically, our studies assessed the possibility that oxalate-induced changes in IEG expression are mediated by phospholipase A2 (PLA2), a common pathway in cellular stress responses.
- Publication
Kidney international, 2000, Vol 58, Issue 2, p638
- ISSN
0085-2538
- Publication type
Journal Article
- DOI
10.1046/j.1523-1755.2000.00210.x