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Title
Cultured human glomerular mesangial cells express the C5a receptor.
Authors
Braun, M; Davis, A E, 3rd
Abstract
While the association of complement activation and glomerulonephritis has been recognized for decades, the pathogenic mechanisms of complement-mediated glomerular damage are incompletely understood. Expression of the C5a receptor in the kidney suggests that C5a could play a direct role in initiating or promoting glomerulonephritis.