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- Title
ORIGINAL ARTICLE Mutations of the BRAF Gene in Benign and Malignant Melanocytic Lesions.
- Authors
Yazdi, Amir S.; Palmedo, Gabriele; Flaig, Michael J.; Puchta, Ursula; Reckwerth, Andrea; Rütten, Arno; Mentzel, Thomas; Hügel, Heino; Hantschke, Markus; Monika-Hildegard, Markus; Schmidt-Wendtmer, Markus; Kutzner, Heinz; Sander, Christian A.
- Abstract
A single-point mutation in exon 15 of the BRAF gene has recently been reported in a high percentage in cultured melanoma cells and in 6 of 9 primary melanomas examined. To evaluate the impact of the T1796A BRAF mutation, we screened primary melanomas, various types of nevi and lesions where a melanoma developed in an underlying nevus. We could detect the mutation in 28 of 97 (29%) melanomas and in 39 of 187 (21%) nevi, including blue nevi (0/20) and Spitz nevi (0/69), which did not carry the mutation. In melanomas with an underlying nevus, either the mutation was present in both the laser-microdissected nevus cells and the laser-microdissected melanoma cells (3/14) or both lesions were negative for the BRAF mutation except one case. In conclusion, mutations in exon 15 of the BRAF gene are nonspecific for progression of a nevus to a melanoma. Other so far unknown cofactors seem to be of importance.
- Publication
Journal of Investigative Dermatology, 2003, Vol 121, Issue 5, p1160
- ISSN
0022-202X
- Publication type
Academic Journal
- DOI
10.1046/j.1523-1747.2003.12559.x