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- Title
The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS.
- Authors
Chen, G; Zeng, W Z; Yuan, P X; Huang, L D; Jiang, Y M; Zhao, Z H; Manji, H K
- Abstract
Differential display of mRNA was used to identify concordant changes in gene expression induced by two mood-stabilizing agents, lithium and valproate (VPA). Both treatments, on chronic administration, increased mRNA levels of the transcription factor polyomavirus enhancer-binding protein (PEBP) 2beta in frontal cortex (FCx). Both treatments also increased the DNA binding activity of PEBP2 alphabeta and robustly increased the levels of bcl-2 (known to be transcriptionally regulated by PEBP2) in FCx. Immunohistochemical studies revealed a marked increase in the number of bcl-2-immunoreactive cells in layers 2 and 3 of FCx. These novel findings represent the first report of medication-induced increases in CNS bcl-2 levels and may have implications not only for mood disorders, but also for long-term treatment of various neurodegenerative disorders.
- Publication
Journal of neurochemistry, 1999, Vol 72, Issue 2, p879
- ISSN
0022-3042
- Publication type
Journal Article
- DOI
10.1046/j.1471-4159.1999.720879.x