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- Title
Case Report Aggressive angiomyxoma in the scrotum expressing androgen and progesterone receptors.
- Authors
Chihara, Yoshitomo; Fujimoto, Kiyohide; Takada, Satoshi; Hirayama, Akihide; Cho, Masaki; Yoshida, Katsunori; Ozono, Seiichiro; Hirao, Yoshihiko
- Abstract
Aggressive angiomyxoma is a rare benign mesenchymal myxoid tumor that arises from the pelvic soft tissues and perineum in relatively young females. This tumor has the ability to infiltrate locally and has a high risk of local recurrence after extirpation, but no potential to metastasize. We report here a rare case of aggressive angiomyxoma that developed in the scrotum of a 47-year-old male. Immunostaining of the resected specimen revealed that the tumor cell nuclei stained strongly and diffusely for androgen receptors (80% of the tumor cells), and moderately and partly for progesterone receptors (20% of the tumor cells). However, staining was negative for estrogen receptors. It is highly suggested that the growth of aggressive angiomyxoma in males may depend on androgen manipulation, contrary to its frequent and close association with estrogen receptor expression, which has been reported in females.
- Publication
International Journal of Urology, 2003, Vol 10, Issue 12, p672
- ISSN
0919-8172
- Publication type
Academic Journal
- DOI
10.1046/j.1442-2042.2003.00716.x