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- Title
Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate.
- Authors
Finsterer, J; Pelzl, G; Hess, B
- Abstract
It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia. A 67-year-old woman with symptomatic epilepsy since age 6 years, classified as Lennox-Gasteau syndrome, developed severe, isolated thrombocytopenia of 5 GIGA/L (normal: 150-360 GIGA/L) after being on CBZ (1200 mg/day) for 15 days and additional VPA (300 mg/day) for 5 days in combination. After discontinuation of CBZ and VPA and two thrombocyte transfusions, the thrombocyte count normalized within 3 days. Because she had been taking VPA for only 5 days in addition to CBZ, it could not be confirmed whether it was CBZ alone or the combination of CBZ and VPA that was responsible for the severe thrombocytopenia.
- Publication
Psychiatry and clinical neurosciences, 2001, Vol 55, Issue 4, p423
- ISSN
1323-1316
- Publication type
Journal Article
- DOI
10.1046/j.1440-1819.2001.00885.x