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- Title
Leucocyte populations in respiratory syncytial virus-induced bronchiolitis.
- Authors
Forsyth, Kevin; Smith, PK; Wang, S-Z; Dowling, KD; Forsyth, KD
- Abstract
Objectives: To enumerate the cellular composition of the airways in infants with acute bronchiolitis. Methodology: Cells were obtained by airway lavage from the upper and lower airway and the peripheral blood of infants with respiratory syncytial virus (RSV)+ bronchiolitis, RSV– bronchiolitis and age-matched controls. Results: Neutrophils are the predominant cells present in the upper and lower airway. Neutrophils are present at a higher number/unit volume in the airway than in the peripheral blood. Conclusions: Neutrophils, being the dominant cellular infiltrate into the airway, are likely to contribute to the pathophysiology of bronchiolitis. Therapies targeted at limiting neutrophil influx or neutrophil-mediated damage in the airway may have a therapeutic role.
- Publication
Journal of Paediatrics & Child Health, 2001, Vol 37, Issue 2, p146
- ISSN
1034-4810
- Publication type
Academic Journal
- DOI
10.1046/j.1440-1754.2001.00618.x