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- Title
Prevalence of vaccine-induced escape mutants of hepatitis B virus in the adult population in China: a prospective study in 176 restaurant employees.
- Authors
He, C; Nomura, F; Itoga, S; Isobe, K; Nakai, T
- Abstract
Hepatitis B virus (HBV) variants with mutations in the S gene would pose a substantial risk to the community as current HBV vaccines are not effective in preventing infection with them. The majority of such vaccine escape mutants so far reported have been found while studying vertical transmission of HBV; the vaccine failure rate in connection with vaccine escape mutants in adults is not clear at the moment. The purpose of this study was to evaluate the efficacy of immunization against HBV in the adult population by analysis using polymerase chain reaction (PCR) to detect HBV-DNA, and also to elucidate the type of mutation encountered in vaccine failure cases.
- Publication
Journal of gastroenterology and hepatology, 2001, Vol 16, Issue 12, p1373
- ISSN
0815-9319
- Publication type
Journal Article
- DOI
10.1046/j.1440-1746.2001.02654.x