We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neutralization of proANP (1-30) exacerbates hypertension in the spontaneously hypertensive rat.
- Authors
Dietz, John R; Vesely, David L; Gower, William R; Landon, Carol S; Lee, Sook Jeong; Nazian, Stanley J
- Abstract
1. The aim of the present studies was to determine the role of proANP (1-30) in the regulation of arterial pressure. It was hypothesized that blocking endogenous proANP (1-30) would exacerbate the hypertension in susceptible animal models. 2. Pentobarbital-anaesthetized spontaneously hypertensive rats (SHR) were pretreated i.v. with 1.2 mL rabbit serum containing an antibody directed specifically against rat proANP (1-30) (SHR-AB group; n = 7) or an equal volume of normal rabbit serum as a control (SHR-NRS group; n = 5). 3. Following a 1 h equilibration period and two 30 min baseline periods, rats were volume expanded with 3 mL of 6% albumin in Krebs' solution and observed for an additional 3 h to determine the effects of the anti-proANP on arterial pressure. 4. Arterial pressure increased in both groups compared with their own baselines with volume expansion, but was significantly greater in the anti-proANP SHR group compared with the SHR-NRS group throughout the volume expansion period. A maximum difference of 21 mmHg between the anti-proANP SHR group and the NRS-SHR group was observed at 150 min of the study (183 +/- 5 vs 162 +/- 3 mmHg, respectively; P < 0.005. 5. These results suggest a protective role for proANP (1-30) in the SHR model of hypertension.
- Publication
Clinical and experimental pharmacology & physiology, 2003, Vol 30, Issue 9, p627
- ISSN
0305-1870
- Publication type
Journal Article
- DOI
10.1046/j.1440-1681.2003.03888.x