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- Title
SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli.
- Authors
Espeli, Olivier; Nurse, Pearl; Levine, Cindy; Lee, Chong; Marians, Kenneth J
- Abstract
SetB was identified as a high-copy suppressor of the partition defect of a mutation in parC, encoding one of the subunits of topoisomerase IV. Deletion of this integral inner membrane protein causes a delay in chromosome segregation, whereas its overproduction causes nucleoid disintegration and stretching, leading to a cell division defect. setB deletion mutants also exhibit a synthetic phenotype when combined with mutations that delete the C-terminal motor domain of the septal ring protein FtsK. SetB localizes in the cell as a helix and interacts with MreB, the bacterial actin homologue, which also forms a helix. These observations suggest that there may be a link between chromosome segregation and cellular infrastructure.
- Publication
Molecular microbiology, 2003, Vol 50, Issue 2, p495
- ISSN
0950-382X
- Publication type
Journal Article
- DOI
10.1046/j.1365-2958.2003.03736.x