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- Title
Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus.
- Authors
Nagaev, I; Björkman, J; Andersson, D I; Hughes, D
- Abstract
Fusidic acid resistance resulting from mutations in elongation factor G (EF-G) of Staphylococcus aureus is associated with fitness costs during growth in vivo and in vitro. In both environments, these costs can be partly or fully compensated by the acquisition of secondary intragenic mutations. Among clinical isolates of S. aureus, fusidic acid-resistant strains have been identified that carry multiple mutations in EF-G at positions similar to those shown experimentally to cause resistance and fitness compensation. This observation suggests that fitness-compensatory mutations may be an important aspect of the evolution of antibiotic resistance in the clinical environment, and may contribute to a stabilization of the resistant bacteria present in a bacterial population.
- Publication
Molecular microbiology, 2001, Vol 40, Issue 2, p433
- ISSN
0950-382X
- Publication type
Journal Article
- DOI
10.1046/j.1365-2958.2001.02389.x