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- Title
Gonococcal lipooligosaccharide is a ligand for the asialoglycoprotein receptor on human sperm.
- Authors
Harvey, H A; Porat, N; Campbell, C A; Jennings, M; Gibson, B W; Phillips, N J; Apicella, M A; Blake, M S
- Abstract
In the present study, we show that Neisseria gonorrhoeae lipooligosaccharide (LOS) can bind to the asialoglycoprotein receptor (ASGP-R) on human sperm. This work demonstrates the presence of ASGP-R on human sperm. Binding of purified ASGP-R ligand decreased in the presence of gonococci. Binding of purified iodinated gonococcal LOS identified a protein of molecular weight corresponding to that of human ASGP-R. The presence of excess unlabelled LOS blocked binding of iodinated gonococcal LOS. Binding of wild-type gonococcal LOS to sperm was higher than that of mutant LOS lacking the galactose ligand for ASGP-R. These data suggest that the ASGP-R on human sperm cells recognizes and binds wild-type gonococcal LOS. This interaction may contribute to the transmission of gonorrhea from infected males to their sexual partners.
- Publication
Molecular microbiology, 2000, Vol 36, Issue 5, p1059
- ISSN
0950-382X
- Publication type
Journal Article
- DOI
10.1046/j.1365-2958.2000.01938.x