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- Title
Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.
- Authors
Wulffelé, M G; Kooy, A; Lehert, P; Bets, D; Ogterop, J C; Borger van der Burg, B; Donker, A J M; Stehouwer, C D A
- Abstract
Metformin is a key treatment option in type 2 diabetes. However, metformin may decrease vitamin B12 levels and increase levels of homocysteine, a cardiovascular risk factor. We investigated whether 16 weeks of treatment with metformin affects serum concentrations of homocysteine, folate and vitamin B12 in subjects with type 2 diabetes treated with insulin.
- Publication
Journal of internal medicine, 2003, Vol 254, Issue 5, p455
- ISSN
0954-6820
- Publication type
Journal Article
- DOI
10.1046/j.1365-2796.2003.01213.x