We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Diabetes and advanced glycation endproducts.
- Authors
Vlassara, H; Palace, M R
- Abstract
Bio-reactive advanced glycation endproducts (AGE) alter the structure and function of molecules in biological systems and increase oxidative stress. These adverse effects of both exogenous and endogenously derived AGE have been implicated in the pathogenesis of diabetic complications and changes associated with ageing including atherosclerosis, renal, eye and neurological disease. Specific AGE receptors and nonreceptor mechanisms contribute to these processes but also assist in the removal and degradation of AGE. The final disposal of AGE depends on renal clearance. Promising pharmacologic strategies to prevent AGE formation, reduce AGE toxicity, and/or inactivate AGE are under investigation.
- Publication
Journal of internal medicine, 2002, Vol 251, Issue 2, p87
- ISSN
0954-6820
- Publication type
Journal Article
- DOI
10.1046/j.1365-2796.2002.00932.x