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- Title
Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.
- Authors
Yamauchi-Takihara, K; Kishimoto, T
- Abstract
Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besides various well-established mechanisms by which cardiac growth and myocardial remodeling are regulated, gp130 signalling may be a newly discovered mechanism that regulates these events in association with cytoprotective effect in myocardial diseases.
- Publication
International journal of experimental pathology, 2000, Vol 81, Issue 1, p1
- ISSN
0959-9673
- Publication type
Journal Article
- DOI
10.1046/j.1365-2613.2000.00139.x