We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Do self-perpetuating B lymphocytes drive human autoimmune disease?
- Authors
Edwards, J C; Cambridge, G; Abrahams, V M
- Abstract
Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are indications that T-lymphocyte control has been subverted by self-perpetuating B lymphocytes. Potential mechanisms in other autoimmune states are less clear, but a number of observations suggest that misappropriation of immunological memory by B lymphocytes may be a common feature of human autoantibody-associated disease. Put simply, autoantibodies drive their own production. If so, the availability of safe B-lymphocyte-depleting agents provides a potential means for reversal of autoimmunity.
- Publication
Immunology, 1999, Vol 97, Issue 2, p188
- ISSN
0019-2805
- Publication type
Journal Article
- DOI
10.1046/j.1365-2567.1999.00772.x