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- Title
The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study.
- Authors
Stewart, M; Turley, H; Cook, N; Pezzella, F; Pillai, G; Ogilvie, D; Cartlidge, S; Paterson, D; Copley, C; Kendrew, J; Barnes, C; Harris, A L; Gatter, K C
- Abstract
Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to assess KDR activation and novel inhibitors of KDR activation in clinical trials.
- Publication
Histopathology, 2003, Vol 43, Issue 1, p33
- ISSN
0309-0167
- Publication type
Journal Article
- DOI
10.1046/j.1365-2559.2003.01644.x