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- Title
Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen.
- Authors
Ibe, S; Fujita, K; Toyomoto, T; Shimazaki, N; Kaneko, R; Tanabe, A; Takebe, I; Kuroda, S; Kobayashi, T; Toji, S; Tamai, K; Yamamoto, H; Koiwai, O
- Abstract
The repertoires of Ig and TcR are generated by a combinatorial rearrangement of variable (V), diversity (D), and joining (J) segments (V(D)J recombination) in B- and T-cells. Terminal deoxynucleotidyltransferase (TdT) adds extra nucleotides (N nucleotides) at the junctions of the gene segments to enhance the Ig and TcR genes diversity. Using an anti-TdT antibody column, TdT has been purified as a member of a megadalton protein complex from rat thymus. The N region would be synthesized with the large protein complex.
- Publication
Genes to cells : devoted to molecular & cellular mechanisms, 2001, Vol 6, Issue 9, p815
- ISSN
1356-9597
- Publication type
Journal Article
- DOI
10.1046/j.1365-2443.2001.00460.x