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- Title
A human homologue of yeast anti-silencing factor has histone chaperone activity.
- Authors
Munakata, T; Adachi, N; Yokoyama, N; Kuzuhara, T; Horikoshi, M
- Abstract
Structural changes in chromatin play essential roles in regulating eukaryotic gene expression. Silencing, potent repression of transcription in Saccharomyces cerevisiae, occurs near telomeres and at the silent mating-type loci, as well as at rDNA loci. This type of repression relates to the condensation of chromatin that occurs in the heterochromatin of multicellular organisms. Anti-silencing is a reaction by which silenced loci are de-repressed. Genetic studies revealed that several factors participate in the anti-silencing reaction. However, actions of factors and molecular mechanisms underlying anti-silencing remain unknown.
- Publication
Genes to cells : devoted to molecular & cellular mechanisms, 2000, Vol 5, Issue 3, p221
- ISSN
1356-9597
- Publication type
Journal Article
- DOI
10.1046/j.1365-2443.2000.00319.x