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- Title
Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.
- Authors
Nishizawa, M; Nakajima, T; Yasuda, K; Kanzaki, H; Sasaguri, Y; Watanabe, K; Ito, S
- Abstract
20alpha-Hydroxysteroid dehydrogenase (HSD) is a member of the aldo-keto reductase (AKR) superfamily and catalyses the reaction of progesterone to the inactive form 20alpha-hydroxyprogesterone. Progesterone plays an important role in the maintenance of pregnancy, and, in rodents, plasma progesterone levels decrease abruptly just before parturition. The induction of 20alpha-HSD is thought to be responsible for the decrease in plasma progesterone at term. High homology between human 20alpha-HSD [AKR 1C1] cDNA with other AKRs had caused difficulty in gene isolation and expression analysis. Thus, the metabolism of progesterone in the human reproductive system remained unclear.
- Publication
Genes to cells : devoted to molecular & cellular mechanisms, 2000, Vol 5, Issue 2, p111
- ISSN
1356-9597
- Publication type
Journal Article
- DOI
10.1046/j.1365-2443.2000.00310.x