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- Title
The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes.
- Authors
Lieber, M R
- Abstract
Recent progress over the past year has provided new insights into the proteins involved in nonhomologous end joining. The assembly of Ku and DNA-dependent protein kinase at DNA ends is now understood in greater detail. Murine genetic knockouts for DNA ligase IV and XRCC4 are embryonic lethal, indicating that nonhomologous end joining is essential for viability. Interestingly, neurones, in addition to lymphocytes, are particularly vulnerable to an absence of NHEJ.
- Publication
Genes to cells : devoted to molecular & cellular mechanisms, 1999, Vol 4, Issue 2, p77
- ISSN
1356-9597
- Publication type
Journal Article
- DOI
10.1046/j.1365-2443.1999.00245.x