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- Title
AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC.
- Authors
Taira, T; Maëda, J; Onishi, T; Kitaura, H; Yoshida, S; Kato, H; Ikeda, M; Tamai, K; Iguchi-Ariga, S M; Ariga, H
- Abstract
The c-myc proto-oncogene has been suggested to play key roles in cell proliferation, differentiation, transformation and apoptosis. A variety of functions of C-MYC, the product of c-myc, are attributed to protein-protein interactions with various cellular factors including Max, YY1, p107, Bin1 and TBP. Max and YY1 bind to the C-terminal region of C-MYC, while p107, Bin1 and TBP bind to the N-terminal region covering myc boxes. The N-terminal region is involved in all the biological functions of C-MYC, and different proteins are therefore thought to interact with the N-terminal region of C-MYC to display different functions.
- Publication
Genes to cells : devoted to molecular & cellular mechanisms, 1998, Vol 3, Issue 8, p549
- ISSN
1356-9597
- Publication type
Journal Article
- DOI
10.1046/j.1365-2443.1998.00206.x