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Title
Effect of Sildenafil on hypertensive lower oesophageal sphincter.
Authors
Bortolotti, M; Pandolfo, N; Giovannini, M; Mari, C; Miglioli, M
Abstract
Sildenafil relaxes the muscle cells of the penis arterioles by inhibiting phosphodiesterase-type 5 (PD-5), inactivating the nitric oxide-stimulated cyclic guanosine monophosphate. We investigated whether this effect of Sildenafil is also displayed on the muscles of the hypertensive lower oesophageal sphincter (LES).
Publication
European journal of clinical investigation, 2002, Vol 32, Issue 9, p682