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- Title
Acetylcholine does not play a major role in mediating the endocrine responses to ghrelin, a natural ligand of the GH secretagogue receptor, in humans.
- Authors
Broglio, Fabio; Gottero, Cristina; Benso, Andrea; Prodam, Flavia; Casanueva, Felipe F; Dieguez, Carlos; van der Lely, Aart Jan; Deghenghi, Romano; Arvat, Emanuela; Ghigo, Ezio
- Abstract
Ghrelin is a 28 amino residue peptide produced predominantly by the stomach with substantially lower amounts deriving from other central and peripheral tissues. Ghrelin is a natural ligand of the GH secretagogue (GHS) receptor (GHS-R) and possesses a potent GH-releasing activity for which the acylation in serine 3 is essential. Ghrelin also possesses other endocrine and non-endocrine activities reflecting central and peripheral GHS-R distribution and stimulates PRL, ACTH and cortisol secretion, has been reported able to induce hyperglycaemia and to decrease insulin levels and has orexigenic activity. Moreover, ghrelin stimulates gastric motility and acid secretion and its action is mediated by acetylcholine which, in turn, is known to play a stimulatory influence on GH, ACTH and insulin secretion.
- Publication
Clinical endocrinology, 2003, Vol 58, Issue 1, p92
- ISSN
0300-0664
- Publication type
Journal Article
- DOI
10.1046/j.1365-2265.2003.01680.x