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- Title
A novel mutation in the pendrin gene associated with Pendred's syndrome.
- Authors
Bogazzi, F; Raggi, F; Ultimieri, F; Campomori, A; Cosci, C; Berrettini, S; Neri, E; La Rocca, R; Ronca, G; Martino, E; Bartalena, L
- Abstract
Pendred's syndrome is an autosomal recessive disorder characterized by goitre, sensorineural deafness and iodide organification defect. It is one of the most frequent causes of congenital deafness, accounting for about 10% of hereditary hearing loss. It is caused by mutations in the pendrin (PDS) gene, a 21 exon gene located on chromosome 7. The aim of this study was to examine an Italian family affected with Pendred's syndrome at the molecular level.
- Publication
Clinical endocrinology, 2000, Vol 52, Issue 3, p279
- ISSN
0300-0664
- Publication type
Journal Article
- DOI
10.1046/j.1365-2265.2000.00930.x