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- Title
Acute myeloid leukaemia with giant granules: association with t(10; 11)(p13; q14) and disseminated intravascular coagulation.
- Authors
Ma, S K; Yip, S F; Wan, T S; Shek, T W; Ching, L M; Yeung, Y M
- Abstract
A 16-year-old Chinese girl presented with AML-M5a. A bone marrow examination showed that the myeloblasts which were overwhelming the marrow contained giant granules (pseudo-Chediak-Higashi anomaly). Her karyotype showed a rare translocation t(10; 11)(p13; q14). Molecular delineation of the translocation breakpoints was not possible. Nonetheless, this case further demonstrates the morphological and phenotypic heterogeneity of acute leukaemia with this translocation. In this girl it was associated with disseminated intravascular coagulation.
- Publication
Clinical and laboratory haematology, 2000, Vol 22, Issue 5, p303
- ISSN
0141-9854
- Publication type
Journal Article
- DOI
10.1046/j.1365-2257.2000.00329.x