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- Title
NAC Manchester Asthma and Allergy Study (<sup>NAC</sup>MAAS): risk factors for asthma and allergic disorders in adults.
- Authors
Simpson, B. M.; Custovic, A.; Simpson, A.; Hallam, C. L.; Walsh, D.; Marolia, H.; Campbell, J.; Woodcock, A
- Abstract
Asthma and atopic disorders are the most common chronic diseases in the developed countries. Knowledge of the risk factors for these disorders may facilitate the development of preventive strategies aimed at reducing prevalence rates. To investigate the risk factors for asthma and allergic diseases in a large number of adults who are the parents of children in the National Asthma Campaign Manchester Asthma and Allergy Study. All pregnant women and their partners attending ‘Booking’ antenatal clinics were invited to take part in the study. Questionnaire data were collected including the history of asthma and other atopic diseases, pet ownership and smoking habits, and skin prick tests were performed. The prevalence of atopy and the risk factors for asthma and allergic disorders were investigated in all subjects who completed the questionnaire and underwent skin testing. Statistical analysis was carried out using logistic regression. Initially, risk factors were assessed by univariate analysis to see how each potential explanatory variable affected the probability of having allergic disease. Variables were then tested in a forward stepwise multivariate analysis. In 5687 adult subjects there was a very high (48.2%) prevalence of atopy, and 9.7% of subjects had a diagnosis of asthma. In a multivariate regression analysis sensitization to dust mite, cat, dog and mixed grasses were all independently associated with asthma. The odds ratios for current asthma increased with the increasing number of positive skin tests (any two allergens – OR 4.3, 95% CI 3.3–5.5; any three allergens – OR 7.0 95% CI 5.3–9.3; all four allergens – OR 10.4, 95% CI 7.7–14; P < 0.00001). Dog ownership (OR 1.31, 95% CI 1.10–1.57; P = 0.003) and current smoking (OR 1.36, 95% CI 1.15–1.62; P = 0.0004) were significantly and directly associated with ’asthma ever’. Thirteen per cent of participants reported a...
- Publication
Clinical & Experimental Allergy, 2001, Vol 31, Issue 3, p391
- ISSN
0954-7894
- Publication type
Academic Journal
- DOI
10.1046/j.1365-2222.2001.01050.x