We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Granulomatous slack skin disease--disease features and response to pentostatin.
- Authors
Osuji, Nnenna; Fearfield, Louise; Matutes, Estella; Wotherspoon, Andrew C; Bunker, Christopher; Catovsky, Daniel
- Abstract
Granulomatous slack skin disease (GSSD) is a rare condition characterized clinically by redundant skin folds, which show a predilection towards flexural areas, and histologically by a granulomatous T-cell infiltrate and loss of elastic fibres. The disease is often indolent, although rapid progression and transformation have been described. There is much debate as to whether this condition is a subset of mycosis fungoides or a separate disease entity in itself. We describe a case of GSSD with unique manifestations including granulomatous bone marrow involvement and hypercalcaemia. The patient has twice achieved a good response to pentostatin after failure of combination chemotherapy. This is the first report of the successful use of the purine analogue pentostatin in the management of GSSD.
- Publication
British journal of haematology, 2003, Vol 123, Issue 2, p297
- ISSN
0007-1048
- Publication type
Journal Article
- DOI
10.1046/j.1365-2141.2003.04592.x