We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-term complete haematological and molecular remission after allogeneic bone marrow transplantation in a patient with a stem cell myeloproliferative disorder associated with t(8;13)(p12;q12).
- Authors
Suzan, Florence; Guasch, Géraldine; Terre, Christine; Garcia, Isabel; Bastie, Jean-Noël; Maarek, Odile; Ribaud, Patricia; Gluckman, Eliane; Daniel, Marie-Thérèse; Pébusque, Marie-Josèphe; Castaigne, Sylvie
- Abstract
A rare atypical myeloproliferative disorder (aMPD) associated with chromosomal translocations involving the short arm of chromosome 8, region p11-p12 has been described. In most patients, the cytogenetic abnormality is a t(8;13)(p12;q12) that fuses fibroblast growth factor receptor 1, the 8p12 key gene, to FIM/ZNF198 gene. Prognosis is poor with frequent evolution to acute myeloid leukaemia within 1 year of diagnosis. We report a new patient with aMPD with a t(8;13) translocation. Complete haematological, cytogenetic and molecular remission was demonstrated 39 months after allogeneic bone marrow transplantation. This is the first report to demonstrate a molecular remission in this disorder.
- Publication
British journal of haematology, 2003, Vol 121, Issue 2, p312
- ISSN
0007-1048
- Publication type
Journal Article
- DOI
10.1046/j.1365-2141.2003.04269.x