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- Title
Expression of stanniocalcin-1 in megakaryocytes and platelets.
- Authors
Serlachius, Martina; Alitalo, Riitta; Olsen, Henrik S; Andersson, Leif C
- Abstract
Stanniocalcin-1 (STC) is a 56-kDa homodimeric glycoprotein hormone originally found in fish, in which it regulates calcium/phosphate homeostasis and protects against toxic hypercalcaemia. The recently characterized human STC is 80% similar to fish STC. We have earlier reported a high expression of STC in terminally differentiated human and rodent brain neurones, and found that STC contributes to the maintenance of their integrity. Here, we report that mature megakaryocytes and platelets display high STC content. K562 cells, induced to megakaryocytoid differentiation in vitro, acquired expression of STC, which was not seen in untreated K562 cells or cells induced to erythroid differentiation.
- Publication
British journal of haematology, 2002, Vol 119, Issue 2, p359
- ISSN
0007-1048
- Publication type
Journal Article
- DOI
10.1046/j.1365-2141.2002.03916.x