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- Title
The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase.
- Authors
Vinatzer, U; Taplick, J; Seiser, C; Fonatsch, C; Wieser, R
- Abstract
EVI-1 and its variant form, MDS1/EVI1, have been reported to act in an antagonistic manner and be differentially regulated in samples from patients with acute myeloid leukaemia and rearrangements of the long arm of chromosome 3. Here, we show that both EVI-1 and MDS1/EVI1 can repress transcription from a reporter construct containing EVI-1 binding sites and interact with histone deacetylase in mammalian cells. This interaction can be recapitulated in vitro and is mediated by a previously characterized transcription repression domain, whose activity is alleviated by the histone deacetylase inhibitor trichostatin A.
- Publication
British journal of haematology, 2001, Vol 114, Issue 3, p566
- ISSN
0007-1048
- Publication type
Journal Article
- DOI
10.1046/j.1365-2141.2001.02987.x