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- Title
Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population.
- Authors
Kato, A; Fukai, K; Oiso, N; Hosomi, N; Murakami, T; Ishii, M
- Abstract
Netherton's syndrome (NS) is an autosomal recessive disorder characterized by trichorrhexis invaginata ('bamboo hair'), congenital ichthyosiform erythroderma and an atopic diathesis. NS has recently been shown to be due to a defect in the SPINK5 gene, encoding LEKTI, a 15-domain serine protease inhibitor. SPINK5 maps to chromosome 5q31-q32, and has been suggested to be a locus predisposing to atopy in general. Recently, coding polymorphisms in SPINK5 exons 13 and 14 have been reported to be associated with atopy, asthma and atopic dermatitis (AD).
- Publication
The British journal of dermatology, 2003, Vol 148, Issue 4, p665
- ISSN
0007-0963
- Publication type
Journal Article
- DOI
10.1046/j.1365-2133.2003.05243.x