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Title
Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4.
Authors
Foster, D J; Somogyi, A A; Bochner, F
Abstract
To investigate the kinetics of CYP-mediated N-demethylation of methadone in human liver microsomes, and examine the role of stereoselectivity and CYP isoforms involved.
Publication
British journal of clinical pharmacology, 1999, Vol 47, Issue 4, p403