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Title
Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism.
Authors
Gates, S; Miners, J O
Abstract
The plasma clearance of theobromine (TB; 3,7-dimethylxanthine) is known to be induced in cigarette smokers. To determine whether TB may serve as a model substrate for cytochrome P450 (CYP) 1A2, or possibly other isoforms, studies were undertaken to identify the individual human liver microsomal CYP isoforms responsible for the conversion of TB to its primary metabolites.
Publication
British journal of clinical pharmacology, 1999, Vol 47, Issue 3, p299