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Title
Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man.
Authors
Kupferschmidt, H H; Fattinger, K E; Ha, H R; Follath, F; Krähenbühl, S
Abstract
Saquinavir is a potent HIV protease inhibitor whose effectiveness is limited in vivo by its low bioavailability. Since saquinavir is metabolized by CYP3A4, the effect of grapefruit juice, an inhibitor of CYP3A4, was investigated on its bioavailability.
Publication
British journal of clinical pharmacology, 1998, Vol 45, Issue 4, p355