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- Title
Meta-analysis: proton pump inhibitors vs. H<sub>2</sub>-receptor antagonists — their efficacy with antibiotics in Helicobacter pylori eradication.
- Authors
Gisbert, J. P.; Khorrami, S.; Calvet, X.; Gabriel, R.; Carballo, F.; Pajares, J. M.
- Abstract
: It is unknown whether proton pump inhibitors are superior to H2-receptor antagonists in Helicobacter pylori eradication regimens. : To perform a meta-analysis comparing the efficacy of both antisecretors when co-prescribed with antibiotics. : Randomized clinical trials comparing proton pump inhibitors vs. H2-receptor antagonists with the same antibiotics were selected. Data sources included PubMed, the Cochrane Controlled Trials Register and abstracts from congresses up to January 2002. A meta-analysis was performed by combining the odds ratios. : Twenty studies fulfilled the inclusion criteria. In the intention-to-treat analysis, the mean eradication rates with proton pump inhibitors and H2-receptor antagonists plus antibiotics were 74% [95% confidence interval (CI), 71–76%] and 69% (95% CI, 66–71%), respectively. The odds ratio for this comparison was 1.31 (95% CI, 1.09–1.58). The number needed to treat with proton pump inhibitors to achieve eradication success, compared with H2-receptor antagonists, was 25. When studies prescribing very high doses of H2-receptor antagonists (two of the outliers) were excluded, the odds ratio (for proton pump inhibitors vs. H2-receptor antagonists) increased to 1.37, the number needed to treat decreased to 20 and the heterogeneity between the studies decreased. : Overall, proton pump inhibitors are more effective than H2-receptor antagonists when prescribed at usual doses with antibiotics to eradicate H. pylori infection.
- Publication
Alimentary Pharmacology & Therapeutics, 2003, Vol 18, Issue 8, p757
- ISSN
0269-2813
- Publication type
Academic Journal
- DOI
10.1046/j.1365-2036.2003.01766.x