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- Title
Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study.
- Authors
Andus, T; Klebl, F; Rogler, G; Bregenzer, N; Schölmerich, J; Straub, R H
- Abstract
Dehydroepiandrosterone is a steroid hormone used as an 'over-the-counter' drug in the USA. Treatment with dehydroepiandrosterone was effective in randomized controlled trials in patients with systemic lupus erythematosus. Dehydroepiandrosterone sulphate concentrations are decreased in patients with inflammatory bowel disease. Dehydroepiandrosterone inhibits nuclear factor-kappaB and the secretion of interleukin-6 and interleukin-12 via the peroxisome proliferator-activated receptor alpha.
- Publication
Alimentary pharmacology & therapeutics, 2003, Vol 17, Issue 3, p409
- ISSN
0269-2813
- Publication type
Journal Article
- DOI
10.1046/j.1365-2036.2003.01433.x