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- Title
Gastrointestinal safety and tolerance of ibuprofen at maximum over-the-counter dose.
- Authors
Doyle, G; Furey, S; Berlin, R; Cooper, S; Jayawardena, S; Ashraf, E; Baird, L
- Abstract
Delineation of non-steroidal anti-inflammatory drug (NSAID) gastrointestinal toxicity has largely depended on retrospective epidemiologic studies which demonstrate that lower doses of NSAIDs pose a lower risk of gastrointestinal toxicity. Ibuprofen, a propionic acid NSAID, has, in most such studies, exhibited a favourable profile in terms of gastrointestinal bleeding. Since 1984, ibuprofen has been available as a non-prescription analgesic/antipyretic with a limit of 1200 mg/day for 10 days of continuous use. Trials and spontaneously reported adverse experiences suggest that gastrointestinal symptoms and bleeding are rare.
- Publication
Alimentary pharmacology & therapeutics, 1999, Vol 13, Issue 7, p897
- ISSN
0269-2813
- Publication type
Journal Article
- DOI
10.1046/j.1365-2036.1999.00539.x