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- Title
Behavioural responses of gamma-MSH peptides administered into the rat ventral tegmental area.
- Authors
Klusa, V; Svirskis, S; Opmane, B; Muceniece, R; Wikberg, J E
- Abstract
The behavioural effects induced by alpha-, gamma1- and gamma2-MSH peptides (0.3 and 3 nmole per rat) injected into the left ventral tegmental area (VTA) of rats were compared. alpha- and gamma1-MSH caused grooming of comparable magnitude, and also additional vertical activity (rearing). By contrast gamma2-MSH caused a moderate but stable catalepsy, and practically no grooming. Moreover, intra-VTA pre-treatment with gamma2-MSH, 15 min prior to intra-VTA gamma1-MSH, markedly attenuated both the gamma1-induced grooming and vertical activities. The differences in the behavioural response of the MSH peptides indicate that they act differentially on MC receptors in the VTA.
- Publication
Acta physiologica Scandinavica, 1999, Vol 167, Issue 2, p99
- ISSN
0001-6772
- Publication type
Journal Article
- DOI
10.1046/j.1365-201x.1999.00595.x