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- Title
Proposed role of the paraventricular nucleus in cardiovascular deconditioning.
- Authors
Mueller, P J; Cunningham, J T; Patel, K P; Hasser, E M
- Abstract
Cardiovascular deconditioning occurs in individuals exposed to prolonged spaceflight or bedrest and is associated with the development of orthostatic intolerance. Although the precise mechanisms remain to be fully elucidated, astronauts returning from space or bedrest patients returning to normal upright posture present with decreases in plasma volume and alterations in autonomic function. The hindlimb unloaded (HU) rat has been a useful model to study the effects of cardiovascular deconditioning as it mimics many of the changes that occur after spaceflight and bedrest.
- Publication
Acta physiologica Scandinavica, 2003, Vol 177, Issue 1, p27
- ISSN
0001-6772
- Publication type
Journal Article
- DOI
10.1046/j.1365-201X.2003.01044.x