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- Title
New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes.
- Authors
Noguchi, E; Shibasaki, M; Kamioka, M; Yokouchi, Y; Yamakawa-Kobayashi, K; Hamaguchi, H; Matsui, A; Arinami, T
- Abstract
Prostaglandin D2 (PGD2), a major cyclo-oxygenase metabolite of arachidonic acid in mast cells, induces bronchoconstriction in the human lung. It has been reported that mice lacking PGD receptor fail to develop the bronchial hyper-responsiveness upon ovalbumin challenge, suggesting that PGD2 functions as a mediator of allergic asthma.
- Publication
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Vol 32, Issue 1, p93
- ISSN
0954-7894
- Publication type
Journal Article
- DOI
10.1046/j.0022-0477.2001.01261.x