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- Title
New strategies for the treatment of ovarian cancer.
- Authors
Robinson, Elizabeth; Fisher, Natalie; Stamelos, Vasileios; Redman, Charles; Richardson, Alan
- Abstract
Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesis and PARP [poly(ADP-ribose) polymerase] inhibitors appear promising. Pre-clinical studies have identified several potential new therapeutic strategies, and we review the potential for use of BH3 (Bcl-2 homology) mimetics, autotaxin inhibitors and statins to treat ovarian cancer.
- Publication
Biochemical Society transactions, 2014, Vol 42, Issue 1, p125
- ISSN
1470-8752
- Publication type
Journal Article
- DOI
10.1042/BST20130203