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- Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
- Authors
Begley, Tadhg P; Ealick, Steven E; McLafferty, Fred W
- Abstract
The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.
- Publication
Biochemical Society transactions, 2012, Vol 40, Issue 3, p555
- ISSN
1470-8752
- Publication type
Journal Article
- DOI
10.1042/BST20120084