We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Functional roles of protein splicing factors.
- Authors
Chen, Hsin-Chou; Cheng, Soo-Chen
- Abstract
RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small nuclear RNAs and protein factors. DExD/H-box RNA helicases are required to mediate structural changes in the spliceosome at various steps in the assembly pathway and have also been implicated in the fidelity control of the splicing reaction. Other proteins also play key roles in mediating the progression of the spliceosome pathway. In this review, we discuss the functional roles of the protein factors involved in the spliceosome pathway primarily from studies in the yeast system.
- Publication
Bioscience reports, 2012, Vol 32, Issue 4, p345
- ISSN
1573-4935
- Publication type
Journal Article
- DOI
10.1042/BSR20120007