We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
- Authors
Branitzki-Heinemann, Katja; Okumura, Cheryl Y; Völlger, Lena; Kawakami, Yuko; Kawakami, Toshiaki; Naim, Hassan Y; Nizet, Victor; Von Köckritz-Blickwede, Maren
- Abstract
MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).
- Publication
The Biochemical journal, 2012, Vol 446, Issue 1, p159
- ISSN
1470-8728
- Publication type
Journal Article
- DOI
10.1042/BJ20120658