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- Title
Obsessive-Compulsive Disorder, 5-HTTLPR polymorphism and treatment response.
- Authors
Di Bella, D; Erzegovesi, S; Cavallini, M C; Bellodi, L
- Abstract
Recently, a role for a functional polymorphism within the promoter region of the serotonin transporter gene (5-HTTLPR) in conferring susceptibility to Obsessive Compulsive Disorder (OCD) has been suggested. The aim of this study was to test the hypothesis that allelic variation of the 5-HTTLPR could be associated with OCD susceptibility or influence the drug response in OCD. One hundred and eighty-one OCD patients were recruited; 92 patients underwent a standardized treatment with fluvoxamine. No significant differences in allele/genotype distribution of the 5-HTTLPR were found between 191 controls and OCD. No differences in fluvoxamine response in the three genotypes groups in OCD were found, considering Yale-Brown Obsessive Compulsive Scale (YBOCS) total scores. Nevertheless, a significant time per genotype interaction was found for the YBOCS subtotal compulsion scores. Considering patients without tic disorder co-diagnosis, a significant time per genotype interaction for both YBOCS total scores and compulsion scores was found.
- Publication
The pharmacogenomics journal, 2002, Vol 2, Issue 3, p176
- ISSN
1470-269X
- Publication type
Journal Article
- DOI
10.1038/sj.tpj.6500090